Top 12 Amlodipine Side Effects You Might Not Hear About
Amlodipine is a calcium-channel blocker commonly used for high blood pressure and angina. Most people tolerate it well, and many side effects are mild.
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Common effects
Ankle and leg swelling — One of the most characteristic effects. It can become more likely at higher doses; in clinical trials, edema occurred in about 10.8% of people taking 10 mg compared with 3% taking 5 mg.
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What to do: Tell your doctor if swelling persists or bothers you. Don’t simply stop amlodipine.
Dizziness — Particularly noticeable when your blood pressure drops or when you stand up.
What to do: Rise slowly and sit or lie down if you feel faint.
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Headache — Often occurs when starting treatment and may improve as your body adjusts.
Flushing — Your face or neck may suddenly feel warm and look red.
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Palpitations — You may become unusually aware of your heartbeat or notice a faster heartbeat.
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Tiredness or weakness — Fatigue was reported more frequently with amlodipine than placebo in clinical trials.
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Sleepiness — Some people feel unusually sleepy, particularly after beginning treatment.
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Nausea or stomach discomfort — Nausea and abdominal pain are recognized adverse effects.
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Constipation or diarrhea — Changes in bowel habits can occur.
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Muscle cramps or muscle aches — These are less common but have been reported with amlodipine.
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Sleep or mood changes — Insomnia, nervousness, anxiety, depression, and unusual dreams have been reported, although these aren’t among the most common effects.
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Gum enlargement — Gingival hyperplasia is an uncommon reported reaction. Good oral hygiene and regular dental care are particularly important if you notice changes in your gums.
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What about the ankle swelling?
This deserves special attention. Amlodipine-related swelling usually develops over the first few weeks to months or after a dose increase and commonly affects the feet and ankles. It is usually not dangerous, but it can be troublesome. Doctors may consider changing the dose or medication regimen if it’s significant.
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🚨 Rare symptoms that need urgent attention
Seek urgent medical help for difficulty breathing or swelling of the throat/tongue, a severe blistering or peeling skin reaction, or sudden severe abdominal pain. Amlodipine can very rarely be associated with serious reactions, including pancreatitis and severe allergic reactions.
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There is also a very rare possibility of a heart attack or worsening angina when treatment is first started or the dose is increased, particularly in people with significant coronary disease. New or worsening chest pain should be treated urgently.
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Most important: Don’t stop amlodipine on your own. Stopping it can allow blood pressure to rise again and can be dangerous. If a side effect is troubling you, speak with your doctor or pharmacist about whether the dose or treatment should be changed.
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