If you’re using this as a social-media hook, the claim needs a little caution: there isn’t one universally accepted list of exactly five medications that all increase heart-attack and stroke risk in older people. The risk depends heavily on the drug, dose, medical history, and other medicines. The American Geriatrics Society specifically says potentially inappropriate medications are not automatically inappropriate for every older adult.
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American Geriatrics Society
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One well-established example is non-aspirin NSAIDs (such as ibuprofen, naproxen, and diclofenac), which can increase cardiovascular risk, particularly at higher doses and with longer use.
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U.S. Food and Drug Administration
If you want, I can also identify the five medication classes most commonly behind this warning and explain the evidence for each.
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